2021-2022 Varsity Soccer
| Date | | Opponent | Location | Result | | W/L |
|---|
| Fri, Aug 27
| | Lafayette | Lafayette | 2-3 | | L |
| Lafayette | Lafayette |
| Tue, Aug 31
| | Holt | Holt | 2-1 | | W |
| Holt | Holt |
| Thu, Sep 02
| | Rockwood Summit | Rockwood Summit | 3-1 | | W |
| Rockwood Summit | Rockwood Summit |
| Sat, Sep 11
| | Cape Notre Dame | De Smet Jesuit | 0-2 | | L |
| Cape Notre Dame | De Smet Jesuit |
| Tue, Sep 14
| | CBC | CBC | 0-2 | | L |
| CBC | CBC |
| Thu, Sep 16
| | Vianney | CBC | 2-2 | | T |
| Vianney | CBC |
| Sat, Sep 18
| | SLUH | CBC | 2-3 | | L |
| SLUH | CBC |
| Tue, Sep 21
| | Gateway Legacy | De Smet Jesuit High | 0-2 | | L |
| Gateway Legacy | De Smet Jesuit High |
| Thu, Sep 23
| | Chaminade | De Smet Jesuit High | 3-2 | | W |
| Chaminade | De Smet Jesuit High |
| Tue, Sep 28
| | Lindbergh | De Smet Jesuit High | 2-0 | | W |
| Lindbergh | De Smet Jesuit High |
| Thu, Sep 30
| | Vianney | Vianney | 0-2 | | L |
| Vianney | Vianney |
| Sat, Oct 02
| | Priory | De Smet Jesuit High | 6-1 | | W |
| Priory | De Smet Jesuit High |
| Wed, Oct 06
| | CBC | De Smet Jesuit | 1-0 | | W |
| CBC | De Smet Jesuit |
| Tue, Oct 12
| | Eureka | Eureka | 1-0 | | W |
| Eureka | Eureka |
| Thu, Oct 14
| | Columbia Hickman | De Smet Jesuit | 5-2 | | W |
| Columbia Hickman | De Smet Jesuit |
| Fri, Oct 15
| | John Burroughs | John Burroughs | 1-0 | | W |
| John Burroughs | John Burroughs |
| Tue, Oct 19
| | St. Dominic | St. Dominic | 4-5 | | L |
| St. Dominic | St. Dominic |
| Thu, Oct 21
| | SLUH | SLUH | 0-2 | | L |
| SLUH | SLUH |
| Tue, Oct 26
| | Jackson | Jackson | 3-1 | | W |
| Jackson | Jackson |
| Thu, Oct 28
| | Parkway South | Parkway South | 2-1 | | W |
| Parkway South | Parkway South |
| Mon, Nov 01
| | Eureka | De Smet Jesuit | 2-0 | | W |
| Eureka | De Smet Jesuit |
| Tue, Nov 02
| | Marquette | Lafayette | 0-3 | | L |
| Marquette | Lafayette |
