2021-2022 Varsity Football
| Date | | Opponent | Location | Result | | W/L |
|---|
| Fri, Aug 27
| | Edwardsville (IL) | De Smet Jesuit High | 44-17 | | W |
| Edwardsville (IL) | De Smet Jesuit High |
| Fri, Sep 03
| | East St Louis (IL) | East St Louis (IL) | 17-32 | | L |
| East St Louis (IL) | East St Louis (IL) |
| Fri, Sep 10
| | CBC | CBC | 29-44 | | L |
| CBC | CBC |
| Fri, Sep 17
| | Chaminade | De Smet Jesuit High | 33-7 | | W |
| Chaminade | De Smet Jesuit High |
| Fri, Sep 24
| | Vianney | Vianney | 49-0 | | W |
| Vianney | Vianney |
| Fri, Oct 01
| | Roosevelt | Roosevelt | 65-0 | | W |
| Roosevelt | Roosevelt |
| Fri, Oct 08
| | Rockhurst | De Smet Jesuit | 28-14 | | W |
| Rockhurst | De Smet Jesuit |
| Fri, Oct 08
| | Rockhurst | De Smet Jesuit | 28-14 | | W |
| Rockhurst | De Smet Jesuit |
| Fri, Oct 15
| | SLUH | De Smet Jesuit | 48-21 | | W |
| SLUH | De Smet Jesuit |
| Sat, Oct 23
| | Vashon | Vashon | 42-7 | | W |
| Vashon | Vashon |
| Fri, Oct 29
| | Kirkwood | De Smet Jesuit | 35-7 | | W |
| Kirkwood | De Smet Jesuit |
| Fri, Nov 05
| | CBC | CBC | 7-42 | | L |
| CBC | CBC |
