2021-2022 Baseball
| Date | | Opponent | Location | Result | | W/L |
|---|
| Mon, Mar 14
| | Washington | Timperland | 6-2 | | W |
| Washington | Timperland |
| Mon, Mar 14
| | Timberland | Timberland | 3-0 | | W |
| Timberland | Timberland |
| Fri, Mar 18
| | Rockwood Summit | Rockwood Summit | 8-10 | | L |
| Rockwood Summit | Rockwood Summit |
| Sat, Mar 19
| | Sikeston | Sikeston | 14-4 | | W |
| Sikeston | Sikeston |
| Sat, Mar 19
| | Cooter | Sikeston | 7-6 | | W |
| Cooter | Sikeston |
| Fri, Mar 25
| | CBC | De Smet | 0-4 | | L |
| CBC | De Smet |
| Sat, Mar 26
| | CBC | CBC | 6-10 | | L |
| CBC | CBC |
| Mon, Mar 28
| | Francis Howell North | Francis Howell North | 4-5 | | L |
| Francis Howell North | Francis Howell North |
| Fri, Apr 01
| | Smith-Cotton | Francis Howell North | 13-1 | | W |
| Smith-Cotton | Francis Howell North |
| Sat, Apr 02
| | Francis Howell Central | Francis Howell Centr | 2-9 | | L |
| Francis Howell Central | Francis Howell Centr |
| Sat, Apr 02
| | Summit | Francis Howell Centr | 9-3 | | W |
| Summit | Francis Howell Centr |
| Tue, Apr 05
| | Vianney | Vianney | 5-4 | | W |
| Vianney | Vianney |
| Wed, Apr 06
| | Vianney | De Smet Jesuit | 3-0 | | W |
| Vianney | De Smet Jesuit |
| Thu, Apr 07
| | St. Dominic | St. Dominic | 1-7 | | L |
| St. Dominic | St. Dominic |
| Fri, Apr 08
| | Marquette | Marquette | 4-6 | | L |
| Marquette | Marquette |
| Sat, Apr 09
| | Lafayette | Lafayette | 9-11 | | L |
| Lafayette | Lafayette |
| Sat, Apr 09
| | Westminster | Lafayette | 9-6 | | W |
| Westminster | Lafayette |
| Tue, Apr 12
| | St. Louis Patriots | BMAC | 5-6 | | L |
| St. Louis Patriots | BMAC |
| Tue, Apr 19
| | Gateway Legacy Christian | De Smet | 4-3 | | W |
| Gateway Legacy Christian | De Smet |
| Thu, Apr 21
| | Eureka | Eureka | 5-4 | | W |
| Eureka | Eureka |
| Tue, Apr 26
| 4:30 PM | SLUH | De Smet | | | |
| SLUH | De Smet |
| Thu, Apr 28
| 4:30 PM | SLUH | Sheridan Stadium | | | |
| SLUH | Sheridan Stadium |
| Fri, Apr 29
| 4:30 PM | Parkway North | Parkway North | | | |
| Parkway North | Parkway North |
| Sat, Apr 30
| 12:00 PM | Parkway South | Parkway South | | | |
| Parkway South | Parkway South |
| Mon, May 02
| 4:30 PM | Edwardsville | De Smet | | | |
| Edwardsville | De Smet |
| Tue, May 03
| 4:30 PM | Chaminade | Chaminade | | | |
| Chaminade | Chaminade |
| Wed, May 04
| 4:00 PM | Jackson | De Smet | | | |
| Jackson | De Smet |
| Thu, May 05
| 4:30 PM | Chaminade | De Smet | | | |
| Chaminade | De Smet |
| Mon, May 09
| 4:30 PM | Northwest Cedar Hill | Northwest Cedar Hill | | | |
| Northwest Cedar Hill | Northwest Cedar Hill |
| Tue, May 10
| 4:15 PM | Seckman | Seckman | | | |
| Seckman | Seckman |
| Wed, May 11
| 4:30 PM | Priory | De Smet | | | |
| Priory | De Smet |
